紫禁城宫闱深深，幽深曲折，共九千九百九十间。
一个是都市生活中白领剩女，终日忙碌在相亲途中，有朝一日穿回大明，不满宫廷争斗，逃到市井开了家涮肉坊，只是，这生意又能安稳到几时？果不其然，不多日她就稀里糊涂就成了皇太孙的养母......
一个是大明王朝的孤傲王爷，桀骜独立，却不得不在朝堂之上忍辱负重滴血认亲。胸中隐忍多年的暗流，早晚要一涌而出，江山变色。
一个是郁郁不得志的年轻书生，身怀出众之医术，睿智从容，但命运从来不曾垂青于他，他便会安心在书斋中过这一世么？
这三人，时空交错，际遇流转，爱恨也痴缠，一起梦回大明十二年......
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